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Email: vkesler@stanford.edu | Email: vkesler@stanford.edu | ||
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Modern medical assays, used to determine biomolecular concentrations in patient samples, represent a powerful advance in patient care and diagnosis. However, these diagnostics remain limited by cost and accessibility. Most of these assays require multiple sample preparation steps conducted by trained personnel in a lab setting. Additionally, | Modern medical assays, used to determine biomolecular concentrations in patient samples, represent a powerful advance in patient care and diagnosis. However, these diagnostics remain limited by cost and accessibility. Most of these assays require multiple sample preparation steps conducted by trained personnel in a lab setting. Additionally, | ||
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==== Aptamer-based Sensors: | ==== Aptamer-based Sensors: | ||
- | Conventional diagnostic assays rely on antibody-based affinity reagents to bind biomolecular targets. However, these reagents are costly to develop and manufacture and limited in scope of potential targets. Aptamers are an alternative type of affinity reagent, built of oligonucleotides that bind specifically to a target. These reagents are more versatile and can be developed for a wide variety of targets through many different selection schemes, such as SELEX or Particle Display[[1]]. Additionally, | + | Conventional diagnostic assays rely on antibody-based affinity reagents to bind biomolecular targets. However, these reagents are costly to develop and manufacture and limited in scope of potential targets. Aptamers are an alternative type of affinity reagent, built of oligonucleotides that bind specifically to a target. These reagents are more versatile and can be developed for a wide variety of targets through many different selection schemes, such as SELEX or Particle Display[1]. Additionally, |
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==== BioFET | ==== BioFET | ||
- | FET-based biomolecular sensors have been studied extensively, | + | FET-based biomolecular sensors have been studied extensively, |
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- | However, these sensors are often limited by Debye screening in the analyte – an effect that limits the signal. Furthermore, | + | |
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- | [[3]] Chen, T. T., Wen, C.-H., Huang, J.-C., Peng, Y.-C., Liu, S., Su, S.-H., … Chen, M. (2015). A semiconductor bio-electrical platform | + | However, these sensors are often limited by Debye screening in the analyte – an effect that limits the signal. Furthermore, the target molecule is often the source of the charge detected by the sensor. This project seeks to develop a universal, target-agnostic approach by combining novel aptamer-based sensing schemes |
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- | [[4]] Huang, Y.J., Lin, C.C., Huang, J.C., Hsieh, C.H., Wen, C.H., Chen, T.T., Jeng, L.S., Yang, C.K., Yang, J.H., Tsui, F., Liu, Y.S., Liu, S., Chen, M., 2015. High performance dual- gate isfet with non-ideal effect reduction schemes in a soi-cmos bioelectrical soc. In: 2015<br>IEEE International Electron Devices Meeting (IEDM), pp. 29.2.1–29.2.4. http:// | + | [1] Wang, J., Gong, Q., Maheshwari, N., Eisenstein, M., Arcila, M. L., Kosik, K. S., & Soh, H. T. (2014). Particle Display: A Quantitative Screening Method for Generating High-Affinity Aptamers. Angewandte Chemie International Edition, 53(19), 4796–4801. http:// |
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+ | [2] Kaisti, M. (2017). Detection principles of biological and chemical FET sensors. Biosensors and Bioelectronics, | ||
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+ | [3] Chen, T. T., Wen, C.-H., Huang, J.-C., Peng, Y.-C., Liu, S., Su, S.-H., … Chen, M. (2015). A semiconductor bio-electrical platform with addressable thermal control circuits for accelerated bioassay development. In Technical Digest - International Electron Devices Meeting, IEDM (Vol. 2015–Febru, | ||
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+ | [4] Huang, Y.J., Lin, C.C., Huang, J.C., Hsieh, C.H., Wen, C.H., Chen, T.T., Jeng, L.S., Yang, C.K., Yang, J.H., Tsui, F., Liu, Y.S., Liu, S., Chen, M., 2015. High performance dual- gate isfet with non-ideal effect reduction schemes in a soi-cmos bioelectrical soc. In: 2015 \\ | ||
+ | IEEE International Electron Devices Meeting (IEDM), pp. 29.2.1–29.2.4. http:// |